It doesn't mean that if a certain book position cannot be reached by the other moves in the book it is already worthless, it is possible that this can be reached by actual game play and the book move can still be played.
This is not the correct explanation. Unreachable positions are genuinly unreachable
Assume that the book contains only d4 in the initial position but also some moves in the position after e4 e5
(call it P)
Then the moves in position P are useless for white as he will never reach that position when following the book, and this is true independently of what black does.
This situation may arise if you merge a d4 book with an e4 book. The first book takes precedence so in the initial position you will get only d4. However it might be that P is in the second book and as it is not in the first, it will survive the merging process and end up in the merged book.
EDIT: My extension of polyglot "info-book" when started with "-exact" will find such unreachable positions
by doing a 2-ply search in any known book position. Of course there are more sophisticated cases where this strategy is insufficient.